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The Best Pillowcases in 100% Natural Cotton — Soft Where It Counts Most

A pillowcase is the single piece of bedding that spends the most time in direct contact with your skin. That makes the fiber quality, the weave, and the construction more important here than anywhere else on the bed — and it is exactly why ours are made from nothing but 100% natural cotton.

  • Soft & Breathable
    Soft & Breathable
  • Gentle on sensitive skin
    Gentle on sensitive skin
  • Shrink Proof
    Shrink Proof

Fabric Comparison

Which is for you?

Grand Indulgence 1000 Cotton
Luxuriously Thick & Smooth
  • Made with
    100% long-staple cotton, 1000 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Thick
    Static Card Image
Hotel Luxe 800 Cotton
Crisp, Smooth & Soft
  • Made with
    100% long-staple cotton, 800 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Midweight
    Static Card Image
Egyptian Comfort Sateen
Structured & Elevated Softness
  • Made with
    100% extra-long staple Egyptian cotton
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Egyptian Comfort Percale
Crisp, Matte & Comfortable
  • Made with
    100% extra-long staple Egyptian cotton
  • Comfortable Level
    Cool & crisp
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Restful Retreat 600 Cotton
Crisp, Smooth & Soft
  • Made with
    100% long-staple cotton, 600 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Midweight
    Static Card Image
Weekend Soft 500 Cotton
Airy, Smooth & Silky Soft
  • Made with
    100% long-staple cotton, 500 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Everyday Ease 400 Cotton
Smooth & Soft
  • Made with
    100% long-staple cotton, 400 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Organic Percale
Crisp, Relaxed & Extra Gentle
  • Made with
    100% organic cotton
  • Comfortable Level
    Cool & crisp
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Organic Sateen
Soft, Smooth & Naturally Comfortable
  • Made with
    100% organic cotton
  • Comfortable Level
    Soft & smooth
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
The Best Pillowcases in 100% Natural Cotton — Soft Where It Counts Most
The Best Pillowcases in 100% Natural Cotton — Soft Where It Counts Most
Grand Indulgence 1000 Cotton
Luxuriously Thick & Smooth
  • Made with
    100% long-staple cotton, 1000 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Thick
    Static Card Image
Hotel Luxe 800 Cotton
Crisp, Smooth & Soft
  • Made with
    100% long-staple cotton, 800 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Midweight
    Static Card Image
Egyptian Comfort Sateen
Structured & Elevated Softness
  • Made with
    100% extra-long staple Egyptian cotton
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Egyptian Comfort Percale
Crisp, Matte & Comfortable
  • Made with
    100% extra-long staple Egyptian cotton
  • Comfortable Level
    Cool & crisp
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Restful Retreat 600 Cotton
Crisp, Smooth & Soft
  • Made with
    100% long-staple cotton, 600 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Midweight
    Static Card Image
Weekend Soft 500 Cotton
Airy, Smooth & Silky Soft
  • Made with
    100% long-staple cotton, 500 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Everyday Ease 400 Cotton
Smooth & Soft
  • Made with
    100% long-staple cotton, 400 thread count
  • Comfortable Level
    Soft & balanced
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Organic Percale
Crisp, Relaxed & Extra Gentle
  • Made with
    100% organic cotton
  • Comfortable Level
    Cool & crisp
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image
Organic Sateen
Soft, Smooth & Naturally Comfortable
  • Made with
    100% organic cotton
  • Comfortable Level
    Soft & smooth
    Static Card Image
  • Fabric Content
    Lightweight
    Static Card Image

9 products

Type: Pillowcases Set

Grand Indulgence 1000 Sateen Cotton Pillowcase Pair

Regular price $39.99
Sale price $39.99 Regular price $39.99
  • 12+

Type: Pillowcases Set

Signature Egyptian Cotton Percale Pillowcase Pair

Regular price $30.99
Sale price $30.99 Regular price $32.99
-6%
  • 11+
Peak Week Deal

Type: Pillowcases Set

Signature Egyptian Cotton Sateen Pillowcase Pair

Regular price $32.99
Sale price $32.99 Regular price $32.99
  • 10+
Peak Week Deal

Type: Pillowcases Set

Hotel Luxe 800 Sateen Cotton Pillowcase Pair

Regular price $32.99
Sale price $32.99 Regular price $32.99
  • 10+

Type: Pillowcases Set

Restful Retreat 600 Sateen Cotton Pillowcase Pair

Regular price $29.99
Sale price $29.99 Regular price $29.99
  • 31+

Type: Pillowcases Set

Weekend Soft 500 Sateen Cotton Pillowcase Pair

Regular price $22.99
Sale price $22.99 Regular price $22.99
  • 17+

Type: Pillowcases Set

Everyday Ease 400 Sateen Cotton Pillowcase Pair

Regular price $22.99
Sale price $22.99 Regular price $22.99
  • 28+

Type: Pillowcases Set

Natural Organic Cotton Percale Pillowcase Pair

Regular price $22.99
Sale price $22.99 Regular price $22.99
  • 11+

Type: Pillowcases Set

GOTS Certified, 100% Organic Cotton Sateen Pillowcase Pair

Regular price $22.99
Sale price $22.99 Regular price $22.99

Why Editors Love Our Bedding

For a more budget-friendly option, the California Design Den 400 Thread Count Cotton Pillowcases offer a comfortable sleeping surface that looks and feels way more expensive than their price tag. The envelope closure keeps the pillow covered and in place, making the design a great pick for restless sleepers.

The Spruce

If you’re looking for a high-quality cotton sheet set that’s both comfortable and durable, the California Design Den Luxury 100% Cotton Sheets King Set is a great option.

Pixelfy

The good news is you don't have to spend a small fortune on a set of acne-fighting pillowcases. "California Design Den’s Buttery Soft Cotton Sateen pillowcases are soft to the touch and easy to maintain,"

Yahoo Lifestyle

FAQs

Cotton Pillowcases Designed for Soft, Everyday Comfort

Best Pillowcases — Natural Cotton on the Piece of Bedding That Matters Most

Most people spend more time thinking about their sheet sets than their pillowcases — which is understandable, but backwards. A pillowcase is in contact with your skin and hair for eight hours every night, washed more frequently than any other piece of bedding, and the first thing you feel when you lie down. The best pillowcases are not the most expensive ones — they are the ones made from 100% natural cotton fibers, woven to a consistent construction, and finished to hold their softness through years of regular washing. Our pillowcase collection spans sateen, percale, Egyptian cotton, and organic cotton — every weave available in cotton pillowcases across standard, queen, and king sizes.

Sateen Pillowcases — The Smoothest Natural Cotton Surface

Sateen weave brings more threads to the surface than any other cotton construction — producing a smooth, silky-soft hand feel with a subtle natural luminosity that makes a pillowcase feel refined from the first night. Our sateen pillowcases are made from 100% natural cotton, woven to a consistent thread count, and finished with the same smooth seams and neat envelope or Oxford edges as every pillow cover in our range. The natural first choice for anyone who wants the best pillowcases in a softer, drapier weave that feels as good as it looks.

Percale Pillowcases — Crisp, Clean, and Built to Last

Percale pillowcases have a tight, matte structure that gives them a clean, fresh finish and a lighter, more open texture against skin. Crisp out of the dryer, easy to keep looking neat, and honest in construction — percale is the no-fuss everyday choice for anyone who prefers a crisper hand feel on the pillow they sleep on every night. The best pillowcases for those who want a cleaner, more structured feel from their natural cotton bedding.

Egyptian Cotton Pillowcases — Extra-Long Staple, Gold Seal Verified

Made from extra-long staple Egyptian cotton fibers verified by the Cotton Egypt Association, our Egyptian cotton pillowcases offer an exceptionally smooth texture and a natural durability that holds up beautifully across hundreds of washes. The most refined pillowcase in our collection — a hand feel that improves rather than diminishes over time, backed by trusted fiber authenticity. The honest alternative to satin pillowcases for those who want smoothness on natural fiber rather than a synthetic sheen.

White Pillowcases — The Most Versatile Colour, on the Best Cotton

White pillowcases coordinate with everything — every sheet colour, every duvet cover, every bedroom palette. Our white pillowcases are made from 100% natural cotton, piece-dyed for a bright, consistent white finish that holds through regular washing without dulling or yellowing unevenly. Available in sateen and percale weaves across standard, queen, and king sizes — white pillowcases that look as considered after fifty washes as they did on the first night.

High Thread Count Pillowcases — Weight and Smoothness Combined

Thread count in a pillowcase describes the density and weight of the weave — and at higher thread counts, that density translates to a heavier, smoother feel against skin that many sleepers find noticeably more comfortable. Our 600 thread count pillowcases offer a denser, more substantial hand feel — while our 400 thread count pillowcases deliver a lighter everyday softness that suits a wider range of sleepers and seasons. Both are made from 100% natural cotton — choose based on the weight and hand feel you prefer on the pillow you sleep on every night.

Why California Design Den for the Best Pillowcases

A pillowcase gets washed more often than any other piece of bedding — and frequent washing exposes every shortcut a manufacturer takes. Most of our pillowcase we make is tested for pilling resistance, colour retention, and shrinkage in our family-owned facility. 100% natural cotton throughout, finished with neat, consistent seams and properly sized for a clean tuck on any standard, queen, or king pillow. Backed by the Good Housekeeping Seal and trusted by 8 million+ sleepers — the best pillowcases at a price that reflects honest manufacturing, not inflated retail margins.